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CAS RN: 4083-64-1 | 產品號碼: T0998
p-Toluenesulfonyl Isocyanate
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補充產品訊息:
[Handling Notes]
This product may deposit some white solids during storage.
Please use all of the material as soon as possible upon receiving it.
| 產品號碼 | T0998 |
純度/分析方法 
|
>95.0%(T) |
| 分子式 / 分子量 | C__8H__7NO__3S = 197.21 |
| 外觀與形狀（20°C） | Liquid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Moisture Sensitive |
| CAS RN | 4083-64-1 |
| Reaxys-RN | 391287 |
| PubChem Substance ID | 87576806 |
| SDBS (AIST Spectral DB) | 13756 |
| MDL編號 | MFCD00002030 |
產品規格
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(Neutralization titration) | min. 95.0 % |
| NMR | confirm to structure |
性質
| 熔點 | -2 °C |
| 沸點 | 130 °C/6 mmHg |
| flp | 145 °C |
| 比重 | 1.30 |
| 折射率 | 1.53 |
| 溶解性（可溶於） | Acetone, Toluene |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H332 : Harmful if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 : May cause respiratory irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相關法規
| RTECS # | DB9032000 |
運輸資料
| HS編碼* | 2935.90-000 |
Application
Derivatization Reagent of Hydroxyl Group for LC-MS
References
- p-Toluenesulfonyl isocyanate as a novel derivatization reagent to enhance the electrospray ionization and its application in the determination of two stereo isomers of 3-hydroxyl-7-methyl-norethynodrel in plasma
- Development and validation of an LC?ESI/MS/MS method with precolumn derivatization for the determination of betulin in rat plasma
Application
A Novel Hydroxy Protecting Group: Sulfonylcarbamate Group
Typical Procedure:
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
References
Application
Synthesis of N-Acylsulfonamides
Reference
考研文獻
文檔
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產品規格
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