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CAS RN: 58880-19-6 | 產品號碼: T2477
| 產品號碼 | T2477 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__7H__2__2N__2O__3 = 302.37 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
10MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 58880-19-6 |
| Reaxys-RN | 2391788 |
| PubChem Substance ID | 87560260 |
| Merck Index(14) | 9649 |
| MDL編號 | MFCD03848392 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Optical purity(LC) | min. 95.0 ee% |
| NMR | confirm to structure |
性質
| 熔點 | 144 °C(dec.) |
| 比旋光 [α]D | 136° (C=0.3,MeOH) |
| 溶解性（微溶於） | Alcohol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相關法規
| RTECS # | MI5215000 |
運輸資料
| HS編碼* | 2928.00-000 |
Application
Trichostatin A: A Potent Inhibitor of Histone Deacetylases (HDACs) with Potent Antitumor Activity
Trichostatin A(R-enantiomer) was originally developed as an antifungal antibiotic agent isolated from the metabolites of strains of Streptomyces hygroscopicus in 1976.1) From the 1980s onwards, it has been reported that trichostatin A is a potent inhibitor of histone deacetylases (HDACs) with potent antitumor activity.2-7) Trichostatin A causes the induction of cell differentiation and specific inhibition of the cell cycle in the G1 and G2 phases at the very low concentrations.For your reference, trichostatin A (R-enantiomer) is the more active enantiomer (eutomer) of (-)-trichostatin A (S-enantiomer) [T3633] (The product is for research purpose only.)
References
- 1)A new antifungal antibiotic, trichostatin
- 2)Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
- 3)Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
- 4)Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function (a review)
- 5)The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells (a review)
- 6)Trichostatin A - like hydroxamate histone deacetylase inhibitors as therapeutic agents: Toxicological point of view (a review)
- 7)Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A
Application
iPS cell generation boosting compounds
Reference
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
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