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CAS RN: 15318-45-3 | 產品號碼: T2802
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 164.0 to 168.0 °C |
| Specific rotation [a]20/D | +10.0 to +13.0 deg(C=1, EtOH) |
| NMR | confirm to structure |
性質
| 熔點 | 166 °C |
| 比旋光 [α]D | 11° (C=1,EtOH) |
| 溶解性（可溶於） | Ethanol |
GHS
相關法規
| RTECS # | AB6680000 |
運輸資料
| HS編碼* | 2941.40-000 |
Application
Thiamphenicol: A More Potent and Less Toxic Derivative of Chloramphenicol [C2255]
Thiamphenicol was a semi-synthetic chloramphenicol at first in which the nitro moiety of chloramphenicol [C2255] was replaced by a methylsulphone. Thiamphenicol can now be made by total chemical synthesis. Thiamphenicol has broad activity against Gram-positive and Gram-negative aerobes and for some anaerobes. Thiamphenicol has a similar spectrum of activity to that of chloramphenicol, but is more potent and less toxic. Thiamphenicol inhibits protein synthesis in susceptible organisms by binding to specific nucleotides in 23S rRNA within the 50S subunit of a bacterial ribosome.
References
- Chloramphenicol: relation of structure to activity and toxicity (a review)
- A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives
- Effects of chloramphenicol, florfenicol, and thiamphenicol on growth of algae Chlorella pyrenoidosa, Isochrysis galbana, and Tetraselmis chui
- Simultaneous determination and confirmation of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in chicken muscle by liquid chromatography-tandem mass spectrometry
- A critical review of screening methods for the detection of chloramphenicol, thiamphenicol, and florfenicol residues in foodstuffs
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