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CAS RN: 58-46-8 | 產品號碼: T2839
產品號碼 | T2839 |
純度/分析方法 | >99.0%(T)(HPLC) |
分子式 / 分子量 | C__1__9H__2__7NO__3 = 317.43 |
外觀與形狀(20°C) | Solid |
儲存條件 | Refrigerated (0-10°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Air Sensitive,Heat Sensitive |
包裝和容器 | 200MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 58-46-8 |
Reaxys-RN | 40090 |
PubChem Substance ID | 160871211 |
Merck Index(14) | 9182 |
產品規格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 99.0 area% |
Purity(Nonaqueous Titration) | min. 99.0 % |
Melting point | 124.0 to 130.0 °C |
NMR | confirm to structure |
性質
熔點 | 127 °C |
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H302 : Harmful if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
RTECS # | DK2275000 |
運輸資料
HS編碼* | 2933.99-000 |
Application
Tetrabenazine: A Reversible Inhibitor of the Vesicular Monoamine Transporter Type 2 (VMAT2)
Tetrabenazine is a reversible selective inhibitor of the vesicular monoamine transporter type 2 (VMAT2) resulting in decreased uptake of monoamines into synaptic vesicles, breaking down of monoamines by monoamine oxidase (MAO) and depletion of monoamine stores. Therefore, tetrabenazine works as a depletor of monoamines (such as dopamine [A0305], serotonin [S0370], norepinephrine [A0906], and histamine [H0146]) from nerve terminals. Tetrabenazine is metabolitzed by carbonyl reductase to the initial active metabolite dihydrotetrabenazine (HTBZ), a mixture of α-HTBZ and β-HTBZ. HTBZ also inhibits the VMAT2. Although the precise mechanism is unknown, tetrabenazine is effective in treating chorea (Huntington’s disease). In addition, reserpine [R0007] inhibits VMAT. (The product is for research purpose only.)
References
- Tetrabenazine-induced depletion of brain monoamines: Characterization and interaction with selected antidepressants
- Pharmacokinetics of tetrabenazine and its major metabolite in man and rat
- Absolute configuration of (+)-α-dihydrotetrabenazine, an active metabolite of tetrabenazine
- Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A
- Tetrabenazine for the Treatment of Hyperkinetic Movement Disorders: A Review of the Literature
- Development and validation of stability indicating RP-HPLC method for the estimation of tetrabenazine in bulk and pharmaceutical dosage form
考研文獻
文章/手冊
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