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CAS RN: 118292-40-3 | 產品號碼: T3108
| 產品號碼 | T3108 |
純度/分析方法 
|
>98.0%(GC) |
| 分子式 / 分子量 | C__2__1H__2__1NO__2S = 351.46 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 118292-40-3 |
| Reaxys-RN | 8159145 |
| PubChem Substance ID | 253662270 |
| Merck Index(14) | 9081 |
| MDL編號 | MFCD00867628 |
產品規格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 102.0 to 106.0 °C |
性質
| 熔點 | 105 °C |
GHS
| 危險性說明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相關法規
| RTECS # | US5675100 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Tazarotene: A Synthetic Retinoic Acid Receptor (RAR)-β and γ Selective Retinoid
Retinoids exert their biological effects through two families of nuclear receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs). RAR is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans-retinoic acid [R0064] and 9-cis retinoic acid. There are three retinoic acid receptors (RAR-α, β, and γ). Tazarotene is a synthetic RAR-β and γ selective retinoid. Many studies have shown that tazarotene can affect cell proliferation and differentiation through upregulating the expression of tazarotene-induced genes TIG1, TIG2 and TIG3. Tazarotene is used for the treatment of plaque psoriasis and acne vulgaris. (The product is for research purpose only.)
References
- Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin
- Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin
- Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene
- Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis (a review)
- Tazarotene-induced gene 3 is suppressed in basal cell carcinomas and reversed in vivo by tazarotene application
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