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CAS RN: 50679-08-8 | 產品號碼: T3977
| 產品號碼 | T3977 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__3__2H__4__1NO__2 = 471.69 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 50679-08-8 |
| Reaxys-RN | 5857899 |
| PubChem Substance ID | 468593048 |
| MDL編號 | MFCD00079622 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 146.0 to 150.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 148 °C |
| Maximum Wavelength | 260 nm (EtOH) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 0.0963 mg/l 25 °C |
| 溶解性（可溶於） | Methanol, Ethanol |
GHS
相關法規
| RTECS # | TM4969000 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Terfenadine: A Prodrug of Fexofenadine with Selective H1-Receptor Antagonist Activity
Terfenadine is a prodrug of fexofenadine [F0698] (HCl salt) which is a non-sedative antihistamine with selective H1-receptor antagonist activity. Terfenadine is metabolized by intestinal CYP3A4 to fexofenadine which competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked. In addition, it has been reported that terfenadine may reach excessive blood levels when the metabolism is too slow; and which can cause cardiac arrhythmias (prolongation of QT-interval). (The product is for research purpose only.)
References
- Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria
- Terfenadine (A review on description, synthesis, physical properties, analysis, stability, polymorphism and crystal habits, and pharmacokinetics)
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