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CAS RN: 2068-78-2 | 產品號碼: V0129
Vincristine Sulfate
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| 產品號碼 | V0129 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__4__6H__5__6N__4O__1__0·H__2SO__4 = 923.04 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 2068-78-2 |
| Reaxys-RN | 8047628 |
| PubChem Substance ID | 468593101 |
| Merck Index(14) | 9986 |
| MDL編號 | MFCD08706469 |
產品規格
| Appearance | White to Light yellow powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +24.0 to +32.0 deg(C=2, H2O，calcd.on dried substance) |
| Drying loss | max. 15.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 300 °C |
| Maximum Wavelength | 293 nm (MeOH) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 : Fatal if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H341 : Suspected of causing genetic defects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | OH6340000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | II |
| HS編碼* | 2939.79-000 |
Application
Vincristine Sulfate: An Antitumor Vinca Alkaloid
Vincristine Sulfate is an antitumor vinca alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). The exact mechanism of action has not been determined, but vincristine sulfate has been related to the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. Vincristine has been reported to have neurotoxic side effects. However, the liposome encapsulation of vincristine enhances the efficacy of the vincristine antitumor activity while simultaneously decreasing the neurotoxicity associated with it. (The product is for research purpose only.)
References
- Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle (a review)
- The effect of antimicrotubule agents on signal transduction pathways of apoptosis. A review
- Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine
- Vincristine sulfate. (Supplement) (A review with 80 references description, physical properties, isolation, synthesis, pharmacokinetics, preparation and preservation, uses and methods of analysis.)
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