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CAS RN: 133868-46-9 | 產品號碼: V0144
Valnemulin Hydrochloride
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| 產品號碼 | V0144 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__3__1H__5__2N__2O__5S·HCl = 601.28 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (-20°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
250MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 133868-46-9 |
| 相關CAS RN
|
101312-92-9 |
| Reaxys-RN | 14608238 |
| PubChem Substance ID | 354335437 |
| Merck Index(14) | 9911 |
| MDL編號 | MFCD08458958 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 %(excluding counter anion) |
| Elemental analysis(Carbon) | 59.00 to 64.00 % |
| Elemental analysis(Nitrogen) | 4.00 to 5.00 % |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2941.90-000 |
Application
Valnemulin Hydrochloride: A Semisynthetic Antimicrobial Agent belongs to Pleuromutilins
Valnemulin hydrochloride is a semisynthetic antimicrobial agent belongs to pleuromutilins special for animal. It is mainly used for preventing and controlling mycoplasma, Gram-positive bacteria and Gram-negative bacteria infection in pig, bovine, sheep and other poultry. Recently, several studies have been reported that pleuromutilins bind with domain V of 23S RNA at ribosome of pathogenic microorganism, to inhibit peptidyl transferase, to inhibit synthesis of protein, and finally resulting death of pathogenic microorganism and exerting antibacterial activity. (The product is for research purpose only.)
References
- The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome
- Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket
- The pleuromutilin antibiotics: a new class for human use (a review)
- Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health (a review)
- In Vitro and in Vivo Metabolite Profiling of Valnemulin Using Ultra performance Liquid Chromatography-Quadrupole/Time-of-Flight Hybrid Mass Spectrometry
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