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Published TCIMAIL newest issue No.200 | Product Document Searching Made Easy by 2D Code! | TCI Life Science News December 2025 | [Product Highlights] Catechol-containing Methacrylate Monomer for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 211555-04-3 | 產品號碼: W0013
產品規格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 228.0 to 232.0 °C |
| Elemental analysis(Nitrogen) | 10.50 to 11.50 % |
| NMR | confirm to structure |
性質
| 熔點 | 230 °C |
| Maximum Wavelength | 335 nm (MeOH) |
GHS
| 危險性說明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相關法規
運輸資料
| HS編碼* | 2933.59-000 |
Application
WHI-P 154: A Potent Janus-Associated Kinase 3 (JAK3) Inhibitor
WHI-P 154 is a potent Janus-associated kinase 3 (JAK3) inhibitor that displays no activity at JAK1 or JAK2. JAK3 is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STAT). The phosphorylated SATAs are translocated to the nucleus to activate target genes. WHI-P 154 is cytotoxic human glioblastoma cells. Recent reports have indicated that JAK3 is expressed in lymphoid cells and is involved in the signaling of T cell functions. Therefore, the development of a selective JAK3 inhibitor has been shown to have a potential benefit in the treatment of autoimmune disorders. (The product is for research purpose only.)
References
- 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells
- Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
- The specificity of JAK3 kinase inhibitors
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