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CAS RN: 524-12-9 | 產品號碼: W0015
| 產品號碼 | W0015 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__6H__1__0O__7 = 314.25 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 524-12-9 |
| Reaxys-RN | 332398 |
| PubChem Substance ID | 468593123 |
| MDL編號 | MFCD07778564 |
產品規格
| Appearance | White to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 315 °C |
| Maximum Wavelength | 350 nm (MeOH) |
GHS
相關法規
| RTECS # | DF8078630 |
運輸資料
| HS編碼* | 2932.20-000 |
Application
Wedelolactone: A Selective and Irreversible Kinase Inhibitor with Broad Range of Biological Activities
Wedelolactone is a natural coumestan originally isolated from herbal plants, including Eclipta alba and in Wedelia calendulacea.1) It has been reported that wedelolactone is a selective and irreversible kinase inhibitor with broad range of biological activities. For example, wedelolactone is a direct inhibitor of IKK complex that can suppress lipopolysaccharide(LPS)-induced caspase-11 expression,2) an antidote for snake venom,3,4) an inhibitor of topoisomerase IIα,5) and an inducer of caspase-dependent apoptosis in cancer cells.6) (The product is for research purpose only.)
References
- 1) Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea
- 2) Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
- 3) Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae)
- 4) Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA2 myotoxins
- 5) Inhibition of topoisomerase IIα: Novel function of wedelolactone
- 6) Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt
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