MitoBADY: Mitochondria-selective Raman Probe

Mitochondria plays an important role in maintaining cells like energy supply, cell death, regulation of calcium signaling, and cell metabolism. Therefore, live imaging of mitochondria is useful for understanding their relationship to biological processes.

MitoBADY is a Raman probe for mitochondrial imaging developed by Sodeoka et al.¹⁾ MitoBADY consists of a triphenylphosphonium moiety as a lipophilic cation for targeting mitochondria and a bisarylbutadiyne moiety (BADY),²⁾ which exhibits strong Raman intensity. It was confirmed that MitoBADY is useful as a mitochondrial marker in Raman imaging of the HeLa cell. Therefore, MitoBADY is anticipated in the use of a wide range of applications.³⁾

Related Products

M3830

MitoBADY

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5-Ethynyl-2'-deoxyuridine

References

• 1) A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria
  • H. Yamakoshi, A. Palonpon, K. Dodo, J. Ando, S. Kawata, K. Fujita, M. Sodeoka, Bioorg. Med. Chem. Lett. 2015, 25, 664.
• 2) Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells
  • H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, M. Sodeoka, J. Am. Chem. Soc. 2012, 134, 20681.
• 3) MitoBADY-based Raman sensing of neutrophil-like cells
  • A. Adamczyk, A. M. Nowakowska, J. Jakubowska, D. Perez-Guaita, A. Pieczara, O. Mazuryk, W. Mlynarski, A. Wisłocka-Orłowska, K. Majzner, M. Baranska, Sens. Actuators B: Chem. 2025, 422, 136539.

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