Product

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Advantages

• Safe, easy-to-handle and stable liquid
• A practical generator of active CF₃O anion species
• Enables trifluoromethoxylation of electrophilic substrates; alkyl halides and triflates, unsaturated and aromatic compounds
• Useful for synthesis of biologically active compounds and drug discovery studies

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Applications

Trifluoromethoxylation of secondary alcoholic hydroxyl groups

Trifluoromethoxylation of alkyne moiety

In the above reactions, first T4150 reacted with AgF to generate an active CF₃O anion species.

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Related Products

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Related Product Category Page

• Fluorination Reagents [Synthetic Reagents]

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Product Brochure

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References

• Trifluoromethyl Nonaflate: A Practical Trifluoromethoxylating Reagent and its Application to the Regio- and Stereoselective Synthesis of Trifluoromethoxylated Alkenes
  • Z. Lu, T. Kumon, G. B. Hammond, T. Umemoto, Angew. Chem. Int. Ed. 2021, 60, 16171.
• A Fruitful Decade of Organofluorine Chemistry: New Reagents and Reactions
  • F. Qing, X. Liu, J. Ma, Q. Shen, Q. Song, P. Tang, CCS Chem. 2022, 4, 2518.

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