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Antioxidant Carnosic Acid by Chemical Synthesis
No.153(December 2014)
A major antioxidant in rosemary, carnosic acid (1),1) has attracted much attention because of its many biological activities: i.e. neuron protective effects,2a) inhibition of adipocyte differentiation,2b) human 5-lipoxigenase2c) and lipid absorption.2d) We proudly provide carnosic acid via chemical synthesis for a reasonable price.3)
*This product is manufactured under the license from Tokyo University of Agriculture and Technology, by the technology developed by Professor Emeritus Masahiro Tada.
References
- 1)Antioxidative activity
- 2)Biological activities
- a)T. Satoh, K. Kosaka, K. Itoh, A. Kobayashi, M. Yamamoto, Y. Shimojo, C. Kitajima, J. Cui, J. Kamins, S. Okamoto, M. Izumi, T. Shirasawa, S. A. Lipton, J. Neurochem. 2008, 104, 1116.
- b)T. Takahashi, T. Tabuchi, Y. Tamaki, K. Kosaka, Y. Takikawa, T. Satoh, Biochem. Biophys. Res. Commun. 2009, 382, 549.
- c)D. Poeckel, C. Greiner, M. Verhoff, O. Rau, L. Tausch, C. Hörnig, D. Steinhilber, M. Schubert-Zsilavecz, O. Werz, Biochem. Pharmacol. 2008, 76, 91.
- d)K. Ninomiya, H. Matsuda, H. Shimoda, N. Nishida, N. Kasajima, T. Yoshino, T. Morikawa, M. Yoshikawa, Bioorg. Med. Chem. Lett. 2004, 14, 1943.
- a)T. Satoh, K. Kosaka, K. Itoh, A. Kobayashi, M. Yamamoto, Y. Shimojo, C. Kitajima, J. Cui, J. Kamins, S. Okamoto, M. Izumi, T. Shirasawa, S. A. Lipton, J. Neurochem. 2008, 104, 1116.
- 3)Synthesis of carnosic acid
- a)M. Tada, T. Ohkanda, J. Kurabe, Chem. Pharm. Bull. 2010, 58, 27.
- b)M. Tada, PCT Int. Appl. WO 2009060547, 2009.
- c)M. Tada, TCIMAIL 2012, number 150, 2.
- a)M. Tada, T. Ohkanda, J. Kurabe, Chem. Pharm. Bull. 2010, 58, 27.
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