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Protein Kinase Inhibitor
No.171(October 2016)
Isoquinolinesulfonamide derivatives have been developed as protein kinase inhibitors.1) Fasudil hydrochloride (1) is one of the derivatives and inhibits various protein kinases (an example; Tables 1).1-3)
Human embryonic stem (hES) cells are vulnerable to apoptosis upon cellular detachment or dissociation and the cloning efficiency of dissociated hES cells is generally low, for example 0.24~0.83%4) and 0.4%.5) Treatment of hES cells with 1 diminishes the cell-dissociation-induced apoptosis, resulting in the promotion of colony formation by undifferentiated cells (Table 2).6)
References
- 1)Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
- 2)Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
- 3)Specificity and mechanism of action of some commonly used protein kinase inhibitors
- 4)Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture
- 5)Neurotrophins mediate human embryonic stem cell survival
- 6)A ROCK inhibitor permits survival of dissociated human embryonic stem cells
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