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CAS RN: 320-67-2 | Product Number: A2033
5-Azacytidine
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Purity: >98.0%(T)
Synonyms:
- 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
- Ladakamycin
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$42.00
|
2 | 0 | Contact Us | |
| 1G |
$213.00
|
6 | ≥40 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | A2033 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__1__2N__4O__5 = 244.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 320-67-2 |
| Reaxys Registry Number | 620461 |
| PubChem Substance ID | 87559665 |
| Merck Index (14) | 887 |
| MDL Number | MFCD00006539 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 216 °C(dec.) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H340 : May cause genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | XZ3017500 |
Transport Information:
| H.S.code* | 2940.00-000 |
Application
An Inhibitor of DNA Methylation
The cytidine analogs 5-azacytidine and 5-aza-2'-deoxycytidine [A2232] are inhibitors of DNA methyltransferases (DNMTs) which catalyze the transfer of a methyl group to DNA. DNA methylation is an epigenetic factor and plays an important role in regulating gene expression. 5-Azacytidine and 5-aza-2'-deoxycytidine are the currently most advanced agents for epigenetic cancer therapies. (The product is for research purpose only.)
References
- Cellular differentiation, cytidine analogs and DNA methylation
- 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (a review)
- The Role of Methylation in Gene Expression (a review)
- Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
- Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography
Application
Aminophylline: A Water Soluble Theophylline
References
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
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Specifications
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