Maintenance Notice (12:30 AM - 5:30 AM August 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 58-28-6 | Product Number: D6181
Desipramine Hydrochloride
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1-propanamine Hydrochloride
- 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
145,00 €
|
Contact Us | 15 |
|
| 25G |
645,00 €
|
Contact Us | 27 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D6181 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__2N__2·HCl = 302.85 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 58-28-6 |
| Reaxys Registry Number | 4166006 |
| MDL Number | MFCD00058108 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 212.0 to 216.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 214 °C |
| Maximum Absorption Wavelength | 250 nm (H__2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H336 : May cause drowsiness or dizziness. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 200-373-1 |
| RTECS# | HO0525000 |
Transport Information:
| HS Number | 2933998090 |
Application
Desipramine hydrochloride: An Active Tricyclic Antidepressant
Desipramine hydrochloride, a metabolite of imipramine [I0971], is an active tricyclic antidepressant. While the precise mechanism of action of tricyclic antidepressants is unknown, many studies suggest that they restore normal levels of neurotransmitters, such as norepinephrine and serotonin, by blocking the reuptake of these substances from the synapse in the central nervous system. (The product is for research purpose only.)
References
- Clinical Pharmacokinetics of Imipramine and Desipramine
- Studies on the distinction between uptake inhibition and release of [3H] dopamine in rat brain tissue slices
- The tail suspension test: a new method for screening antidepressants in mice
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.