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CAS RN: 134678-17-4 | Product Number: L0217
Lamivudine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3TC
- (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
NT$1,638
|
34 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
NT$9,156
|
≥60 | 0 | It can be shipped in about 2 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | L0217 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__1N__3O__3S = 229.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 134678-17-4 |
| Reaxys Registry Number | 5480511 |
| PubChem Substance ID | 87560180 |
| Merck Index (14) | 5352 |
| MDL Number | MFCD00869739 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 175.0 to 179.0 °C |
| Specific rotation [a]20/D | -137.0 to -147.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 177 °C |
| Specific Rotation | -142° (C=1,MeOH) |
| Solubility in water | Soluble |
| Degree of solubility in water | 70,000 mg/l 20 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P314 : Get medical advice/ attention if you feel unwell. |
Related Laws:
| RTECS# | UW7361333 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Lamivudine: An L-Nucleoside Reverse Transcriptase Inhibitor
Lamivudine is a nucleoside reverse transcriptase inhibitor that active against HIV1, HIV2, and hepatitis B. Lamivudine is a synthetic L-nucleoside analogue of the naturally occurring D-nucleoside 2’-deoxycytidine. Intracellularly, lamivudine is converted by cellular enzymes to the active metabolite, lamivudine-5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxycytidine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine
- Lamivudine A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection
- New and Emerging Treatment of Chronic Hepatitis B (a review)
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