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Published TCIMAIL newest issue No.199
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CAS RN: 71-58-9 | Product Number: M1964
Medroxyprogesterone Acetate
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Purity: >93.0%(GC)
Synonyms:
- Medroxyprogesterone 17-Acetate
- 17α-Acetoxy-6α-methylprogesterone
- 17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione 17-Acetate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€38.00
|
Contact Us | 2 |
|
| 5G |
€124.00
|
3 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M1964 |
Purity / Analysis Method 
|
>93.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__4H__3__4O__4 = 386.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 71-58-9 |
| Reaxys Registry Number | 2066112 |
| PubChem Substance ID | 87560200 |
| MDL Number | MFCD00010483 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 93.0 % |
| Melting point | 203.0 to 209.0 °C |
| Specific rotation [a]20/D | +45.0 to +51.0 deg(C=1, Dioxane) |
Properties (reference)
| Melting Point | 206 °C |
| Specific Rotation | 48° (C=1,Dioxane) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 200-757-9 |
| RTECS# | TU5010000 |
Transport Information:
| HS Number | 2937230000 |
Application
Medroxyprogesterone acetate: Semi-Synthetic Progestational Agent
Medroxyprogesterone acetate (MPA) and megestrol acetate [M1949], semi-synthetic progestational agents, are effective hormonal treatments for metastatic breast cancer in postmenopausal women. The antineoplastic effect may result from inhibition of pituitary gonadotropin production and resultant decrease in estrogen secretion. In addition, MPA has the pregnancy maintaining effect and the anti-estrogen effect. (The product is for research purpose only.)
References
- Pregnancy Maintaining Effect of Synthetic Progestogens in the Rat
- Studies of the So-called Virilizing Effects of Steroids in Female Rat Fetuses
- Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate (a review)
- The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer (a review)
- Determination of the residues of 50 anabolic hormones in muscle, milk and liver by very-high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry
PubMed Literature
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