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Published TCIMAIL newest issue No.198
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CAS RN: 1893-33-0 | Product Number: P2315
Pipamperone
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Purity: >98.0%(HPLC)
Synonyms:
- Floropipamide
- 1'-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€63.00
|
Contact Us | 16 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2315 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__3__0FN__3O__2 = 375.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 1893-33-0 |
| Reaxys Registry Number | 496532 |
| PubChem Substance ID | 354335140 |
| Merck Index (14) | 7455 |
| MDL Number | MFCD00242979 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 10.60 to 11.70 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 126 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | DW1050000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933399990 |
Application
Pipamperone: A Typical Antipsychotic Agent with the Antagonist Properties at 5-HT2A and D4 Receptors
Pipamperone (floropipamide) is a first-generation (typical) antipsychotic agent that belongs to the butyrophenone type, and used for the treatment of schizophrenia. The precise mechanism of action is unknown, but in vitro studies indicate that pipamperone possesses more potent antagonist properties at serotonin 5-HT2A and dopamine D4 than dopamine D2 receptors, and the antagonisms may be related to the therapeutic effect. (The product is for research purpose only.)
References
- Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat
- Effects of selective 5-hydroxytryptamine-2 and nonselective 5-hydroxytryptamine antagonists on the differential-reinforcement-of-low-rate 72-second schedule
- Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor
- Floropipamide (a review)
- Mass spectral characterization of urinary pipamperone metabolites and high-performance liquid chromatography assay for pipamperone plasma levels
- Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: A multi-level, single-sample approach
PubMed Literature
Product Articles
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