TCI offers an extensive catalog of 31,000 high-quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry topics as follows:

• Coupling Activators for Oligonucleotide Synthesis
• Fluorination Using F-TEDA-BF₄
• Suzuki-Miyaura Cross Coupling with PdCl₂(Amphos)₂
• TCI Chemistry Research: TCIMAIL 190

Coupling Activators for Oligonucleotide Synthesis

Phosphoramidite chemistry using coupling activators has become dominant in the synthesis of oligonucleotides, due to its high coupling efficiency and quick turnaround time. TCI offers a lineup of various modified activators, including imidazolium salts with different acidities, which can be used to strike a good balance between the activation of phosphoramidite and reducing undesired detritylation (de-DMT group). For example, imidazolium salts like 1-methyl-1H-benzimidazol-3-ium trifluoromethanesulfonate (= N-MeBIT) [M3384], tetrazoles such as 5-(benzylthio)-1H-tetrazole (= BTT) [B3020], and pyridinium salts such as pyridinium trifluoroacetate (= Py·TFA) [P2920] are available.

TCI Practical Example: Fluorination Using F-TEDA-BF₄

We are proud to introduce the difluorination of acetoacetanilide using F-TEDA-BF₄ [F0358] as a fluorination reagent. You can see various fluorination reagents in this TCI product brochure.

TCI Practical Example: Suzuki-Miyaura Cross Coupling with PdCl₂(Amphos)₂

TCI introduces the Suzuki-Miyaura cross coupling of 3-amino-2-chloropyridine and 2-methylphenylboronic acid by using PdCl₂(Amphos)₂ [B6255] as a catalyst. This reaction proceeds even if the substrate has an unprotected amino group.

TCI Chemistry Research: TCIMAIL 190

Released in August 2022, TCI's latest issue features Asst. Prof. Yuki Sakamoto’s article and Prof. Nagatoshi Nishiwaki’s chemistry chat. We also feature research on:

• Highly Active Palladium Catalyst Applicable to Various Coupling Reactions
• Building Block for Polycyclic Aromatic Compounds: Biphenylene
• Raw Material for Polyimides that Exhibit Excellent Heat Resistance
• Methylene-Bridged [6]CPP
• CC Chemokine Receptor-1 (CCR1) Antagonist
• ROCK Inhibitor

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