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Globo-series Oligosaccharides: Gb3 Ceramide

No.198(March 2025)
G0624
Gb3 Ceramide (1)

Globotriaosylceramide, commonly referred to as Gb3 Ceramide (1), is also known by other names such as CD77, Pk antigen, and ceramide trihexoside (CTH). These alternative terms underscore its significance across diverse disciplines, including glycobiology, immunohematology, toxicology, and oncology.
Fabry disease is one of the conditions associated with 1, characterized by the accumulation of glycosphingolipids (GSLs), including 1, in various tissues. In this context, 1 serves as a biomarker for the disease. GSL accumulation is notably prevalent in organs such as the heart, kidneys, peripheral nerves, eyes, brain, skin, gastrointestinal tract, and auditory system, leading to clinical complications like cardiac dysfunction and kidney damage.1)
Additionally, 1 functions as a key receptor for Shiga toxin, which is produced by Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae.2) Research has further revealed that in several human cancers—such as ovarian, breast, and colon cancer—overexpression of 1 may play a role in inducing resistance to chemotherapy.3)

Globo-series Oligosaccharides: Gb3 Ceramide

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