Safe and Easy-to-handle Trifluoromethoxylating Agent: TFNf | TCI EUROPE N.V.

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Published TCIMAIL newest issue No.199

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Published TCIMAIL newest issue No.199

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Products > Featured Products >

Product

Trifluoromethyl Nonafluoro-1-butanesulfonate (= TfNf)

T4150: Trifluoromethyl Nonafluoro-1-butanesulfonate (= TFNf)

Advantages

Safe, easy-to-handle and stable liquid
A practical generator of active CF₃O anion species
Enables trifluoromethoxylation of electrophilic substrates; alkyl halides and triflates, unsaturated and aromatic compounds
Useful for synthesis of biologically active compounds and drug discovery studies

Applications

Trifluoromethoxylation of secondary alcoholic hydroxyl groups

Trifluoromethoxylation of alkyne moiety

Related Products

I1075: Silver(I) Fluoride
T1100: Tf₂O (= Trifluoromethanesulfonic Anhydride)
D1599: DIPEA (= N,N-Diisopropylethylamine)
T0135: TMABr (= Tetramethylammonium Bromide)

Related Product Category Page

Fluorination Reagents [Synthetic Reagents]

Product Brochure

Safe and Easy-to-handle Trifluoromethoxylating Agent: TFNf (PDF file)

References

Trifluoromethyl Nonaflate: A Practical Trifluoromethoxylating Reagent and its Application to the Regio- and Stereoselective Synthesis of Trifluoromethoxylated Alkenes
- Z. Lu, T. Kumon, G. B. Hammond, T. Umemoto, Angew. Chem. Int. Ed. 2021, 60, 16171.
A Fruitful Decade of Organofluorine Chemistry: New Reagents and Reactions
- F. Qing, X. Liu, J. Ma, Q. Shen, Q. Song, P. Tang, CCS Chem. 2022, 4, 2518.