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CAS RN: 59277-89-3 | Product Number: A1915
Acyclovir
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Purity: >98.0%(HPLC)
Synonyms:
- Acycloguanosine
- 9-[(2-Hydroxyethoxy)methyl]guanine
- Aciclovir
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 1G |
$59.00
|
Contact Us | Contact Us | ≥60 |
|
|
| 5G |
$157.00
|
Contact Us | Contact Us | 30 |
|
|
| 25G |
$516.00
|
8 | 1 | ≥60 |
|
* Items in stock locally typically ship the same day of ordering. Items from Japan stock are able to ship from a US warehouse within 2 weeks after ordering. For additional estimated shipment times, please refer to the Shipping Simulation tool. Note: Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | A1915 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__1N__5O__3 = 225.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 59277-89-3 |
| Reaxys Registry Number | 1219402 |
| PubChem Substance ID | 87559875 |
| SDBS (AIST Spectral DB) | 52102 |
| Merck Index (14) | 146 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 94.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 262 °C |
GHS
| Signal Word | Warning |
| Hazard Statements | H320 : Causes eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Related Laws:
| RTECS# | UP0791400 |
Transport Information:
| HS Number | 2933.99.9701 |
Application
Acyclovir: An Antiherpesvirus Agent
Acyclovir, an acyclic guanine nucleoside analog developed by Elion and Hitchings, is an antiherpesvirus agent like penciclovir [P2164]. Valacyclovir [V0111] is a prodrug of acyclovir. Acyclovir is active against most species in the herpesvirus family. It depends on the activity of the viral enzyme thymidine kinase (TK) to convert the agent to a monophosphate form and subsequently interfere with viral DNA replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to acyclovir, which has extremely low toxicity for human cell. The spectrum of activity of acyclovir against human herpesviruses is similar to that of penciclovir, both compounds having good activity against herpes simplex viruses types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV). Like penciclovir, acyclovir has slight activity against cytomegalovirus (CMV).
References
- Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine
- Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy
- Acyclovir: discovery, mechanism of action, and selectivity (a review)
- Herpes simplex virus resistance to antiviral drugs (a review)
- Highlights in the Discovery of Antiviral Drugs: A Personal Retrospective (a review)
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Specifications
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