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CAS RN: 75-77-4 | Product Number: C0306
Chlorotrimethylsilane
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Purity: >98.0%(GC)
Synonyms:
- Trimethylchlorosilane
- Trimethylsilyl Chloride
- TMCS
- TMS-Cl
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 25ML |
$19.00
|
14 | Ships from Philadelphia the same day* | ≥80 |
|
|
| 100ML |
$22.00
|
≥40 | 12 | ≥40 |
|
|
| 500ML |
$51.00
|
≥40 | 16 | ≥100 |
|
* Items in stock locally typically ship the same day of ordering. Items from Japan stock are able to ship from a US warehouse within 2 weeks after ordering. For additional estimated shipment times, please refer to the Shipping Simulation tool. Note: Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C0306 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__3H__9ClSi = 108.64 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 75-77-4 |
| Reaxys Registry Number | 1209232 |
| PubChem Substance ID | 87565458 |
| SDBS (AIST Spectral DB) | 10585 |
| MDL Number | MFCD00000502 |
Specifications
| Appearance | Colorless to Light yellow to Light orange clear liquid |
| Purity(GC) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | -58 °C |
| Boiling Point | 57 °C |
| Flash point | -28 °C |
| Specific Gravity (20/20) | 0.86 |
| Refractive Index | 1.39 |
| Solubility (soluble in) | Ether, Benzene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H331 : Toxic if swallowed or if inhaled. H312 : Harmful in contact with skin. H314 : Causes severe skin burns and eye damage. H371 : May cause damage to organs. H225 : Highly flammable liquid and vapor. H290 : May be corrosive to metals. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P234 : Keep only in original container. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P390 : Absorb spillage to prevent material damage. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P406 : Store in corrosive resistant container with a resistant inner liner. P405 : Store locked up. |
Related Laws:
| RTECS# | VV2710000 |
Transport Information:
| UN Number (DOT-AIR) | UN1298 |
| Class (DOT-AIR) | 3/8 |
| Packing Group (TCI-A) | II |
| HS Number | 2931.90.9010 |
Application
TCI Practical Example: Chlorination Using TMSCl
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Procedure
-
A mixture of 3-ethyl-3-pentanol (20.0 g, 172 mmol) and TMSCl (20.6 g, 189 mmol) was stirred at 70 °C for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, and the volatile product was evaporated off under reduced pressure. The residue was distilled at atmospheric pressure (130 °C) to afford 3-chloro-3-ethylpentane (15.0 g, 65% yield) as a clear colorless liquid.
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Experimenter’s Comments
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The reaction was monitored by 1H NMR.
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Analytical Data
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3-Chloro-3-ethylpentane
1H NMR (400 MHz, CDCl3); δ 1.78 (q, J = 7.3 Hz, 6H), 0.96 (t, J = 7.3 Hz, 9H).
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Lead Reference
-
- Direct halogenation of alcohols with halosilanes under catalyst- and organic solvent-free reaction conditions
Application
Acetylation of Alcohols using Acetylating Reagents and Acid Catalysts
References
- 1)A Simple Method for the Esterification of Carboxylic Acids Using Chlorosilanes
- 2)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
Trimethylsilylation of Alcohols using TMS Reagents
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
Mono-TMS Protection of Diols using TMS Chloride and HMDS
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
SMe Cleavage/Acetylation of MTM(Methylthiomethyl) Groups using Chlorotrimethylsilane
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17
Application
Deprotection of MOM Groups using Chlorotrimethylsilane
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
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