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Published TCIMAIL newest issue No.198
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CAS RN: 58-08-2 | Product Number: C2042
Caffeine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1,3,7-Trimethylxanthine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€17.00
|
≥40 | ≥100 |
|
| 500G |
€77.00
|
10 | 37 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2042 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__0N__4O__2 = 194.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 58-08-2 |
| Reaxys Registry Number | 17705 |
| PubChem Substance ID | 87558398 |
| Merck Index (14) | 1636 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in hot Methanol | almost transparency |
Properties (reference)
| Melting Point | 238 °C |
| Solubility in water | Slightly soluble |
| Degree of solubility in water | 21.7 g/l |
| Solubility (soluble in) | Chloroform |
| Solubility (slightly sol. in) | Alcohol, Acetone, Benzene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H332 : Harmful if inhaled. H360 : May damage fertility or the unborn child. H412 : Harmful to aquatic life with long lasting effects. |
| Precautionary Statements | P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-362-1 |
| RTECS# | EV6475000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939300000 |
Application
Caffeine: A Non-Selective Adenosine Receptor Antagonist, and an Inhibitor Cell Cycle of Progression
Caffeine is widely contained in foods and beverages and is the most widely consumed central-nervous-system stimulant.1) It has been known that adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Caffeine, a mimic of adenosine, has the opposite effect of adenosine, and causes most of its biological effects via antagonizing all types of adenosine receptors (ARs), such as A1, A2A, A3, and A2B.2) Besides, it has been reported that caffeine is capable of abrogating cell cycle checkpoints in several different mammalian cell types.3,4) Caffeine has been used to help delineate the role of p53 (cellular tumor antigen p53 gene) in the G2 arrest that occurs in response to DNA damage.3) (The product is for research purpose only.)
References
- 1) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use (a review)
- 2) Caffeine and adenosine (a review)
- 3) Regulation of the G2/M transition by p53 (a review)
- 4) The enigmatic effects of caffeine in cell cycle and cancer (a review)
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