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Published TCIMAIL newest issue No.198
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CAS RN: 4205-91-8 | Product Number: D1353
Clonidine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(2,6-Dichloroanilino)-2-imidazoline Hydrochloride
- 2-(2,6-Dichlorophenylamino)-2-imidazoline Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€36.00
|
4 | 19 |
|
| 5G |
€114.00
|
4 | 37 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D1353 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__9Cl__2N__3·HCl = 266.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 4205-91-8 |
| Related CAS RN | 4205-90-7 |
| Reaxys Registry Number | 4163525 |
| PubChem Substance ID | 87567869 |
| Merck Index (14) | 2390 |
| MDL Number | MFCD00036705 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 312 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Ethanol |
| Solubility (slightly sol. in) | Chloroform |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H330 : Fatal if inhaled. H301 : Toxic if swallowed. |
| Precautionary Statements | P260 : Do not breathe dust. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 224-121-5 |
| RTECS# | NJ2490000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2933299090 |
Application
Clonidine Hydrochloride: An α2-Adrenoceptor Agonist
Clonidine hydrochloride, an imidazoline derivative, is an α2-adrenoceptor agonist such as dexmedetomidine hydrochloride [D5062], guanfacine hydrochloride [G0414], moxonidine [M2660] and et al. Clonidine stimulates α2-adrenoceptor in the brain stem, and suppresses sympathetic outflow and decreases vascular resistance resulting in lower blood pressure. (The product is for research purpose only.)
References
- Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidineLysicamine, and Alkaloid PO-3
- α2-Adrenoceptor-mediated hyperpolarization of locus ceruleus neurons: intracellular studies in vivo
- Central blood pressure regulation: involvement of presynaptic or postsynaptic, α1- or α2-adrenoceptors?
- Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla
- Imidazoline antihypertensive drugs: a critical review on their mechanism of action (a review)
- Clonidine hydrochloride (a review on preparation, properties, analysis, and pharmacology)
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