text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 91421-42-0 | Product Number: N0822

9-Nitrocamptothecin

Chemical Structure of 9-Nitrocamptothecin
×
× 9-Nitrocamptothecin

Purity: >98.0%(HPLC)
Synonyms:
  • Rubitecan
Product Documents:
SDS | Specifications | C of A & Other Certificates | Analytical Charts

General Information | Specifications & Properties | Safety & Regulations | Applications & Literature

Explanatory notes for this page

100MG
€225.00
 Contact Us 35  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

Product Number N0822
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__0H__1__5N__3O__6 = 393.36 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 91421-42-0
Reaxys Registry Number 5365063
PubChem Substance ID 87560509
Merck Index (14) 8288
MDL Number

MFCD06656294
Specifications
Appearance White to Yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D +36.0 to +42.0 deg(C=0.4, CHCl3:MeOH=8:2)
Properties (reference)
Melting Point 268 °C
Specific Rotation 39° (C=0.4,CHCl3:MeOH=8:2)
GHS
Related Laws:
Transport Information:
HS Number 2939790090
Application
水不溶性のトポイソメラーゼ I阻害剤，9-ニトロカンプトテシン (9-NC)

9-Nitrocamptothecin (9-NC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. Its metabolite is 9-aminocamptothecin [A2063]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.

References


PubMed Literature


Documents

Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.

The requested SDS is not available.

Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The product with the lot number searched for has been discontinued and related documentation is no longer provided. Please try a different lot number for this product.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.

A sample C of A for this product is not available at this time.

Analytical Charts
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The requested analytical chart is not available. Sorry for the inconvenience.

The product with the lot number searched for has been discontinued and related documentation is no longer provided. Please try a different lot number for this product.
Other Documents

Session Status
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page.
Continue Operation
Your session has timed out. You will be redirected to the HOME page.
Close