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Guanidinylation [Synthetic Reagents]

 The guanidine structure is a basic skeleton of bioactive substances. For instance, saxitoxin and tetrodotoxin derived from puffer toxin, and batzelladine A as an HIV inhibitor in sea sponge are known as compounds bearing a guanidino group. Also pharmaceutical compounds like antimalarial and antimicrobial agents often have guanidine structure. Guanidinylation reagents are used for the synthesis of guanidine derivertives in the drug discovery field.1)


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