轻松扫码查看产品文档 | TCIMAIL No.196 已上新 | TCI试剂——品质可靠，值得信赖
订购方法？联系方式：021-67121386 / Sales-CN@TCIchemicals.com
Maximum quantity allowed is 999
请选择数量
CAS RN: 104227-87-4 | 产品编码: F0842
Famciclovir
×
![]()
×
| 规格 | 单价 | 上海 | 天津 | 日本* | 数量 |
库存详情
|
|---|---|---|---|---|---|---|
| 500MG |
¥120.00
|
2 | 1 | 13 |
|
* 点击“查询”可查看预计发货日期，仅供参考。
* 无具体发货日期的情况，如：显示“8个工作日后发货”，将在您订购日起的8个工作日后发货。
* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足，需两周左右向日本总部调货。
* 对于可分装产品，11:30前的订单，当天发货；11:30后的订单，隔天发货。
* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
* 无具体发货日期的情况，如：显示“8个工作日后发货”，将在您订购日起的8个工作日后发货。
* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足，需两周左右向日本总部调货。
* 对于可分装产品，11:30前的订单，当天发货；11:30后的订单，隔天发货。
* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 103.0 to 107.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 105 °C |
| 最大吸收波长 | 310(EtOH) nm |
| 水溶性 | 微溶 |
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
相关法规
| RTECS# | TY3164000 |
运输信息
| 监管条件代码(*) |
应用
Famciclovir: A Prodrug of Penciclovir
Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)
References
- Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
- Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action
- In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver
- Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
- In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
应用
Studies on the Antiviral Activities of Famciclovir
Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)
References
- Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
- Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action
- In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver
- Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
- In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
参考文献
文章/手册
TCIMail
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。