盲盒好礼,精彩继续 | 轻松扫码查看产品文档 | TCIMAIL No.198 已上新 | TCI试剂——品质可靠,值得信赖
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CAS RN: 50978-45-5 | 产品编码: F0854
N-Formylsaccharin
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* TCI会经常复审储藏条件以对其进行优化,请以在线目录为准,敬请留意。
* 更多信息,请联系营业部:021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求,请联系我们 。
* 无具体发货日期的情况,如:显示“8个工作日后发货”,将在您订购日起的8个工作日后发货。
* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足,需两周左右向日本总部调货。
* 对于可分装产品,11:30前的订单,当天发货;11:30后的订单,隔天发货。
* 如需大包装,请点击“大包装询价”按钮(对于某些产品我们无法提供大包装)。
* TCI会经常复审储藏条件以对其进行优化,请以在线目录为准,敬请留意。
* 更多信息,请联系营业部:021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求,请联系我们 。
产品编码 | F0854 |
纯度/分析方法 | >98.0%(GC) |
分子式/分子量 | C__8H__5NO__4S = 211.19 |
外观与形状(20°C) | 固体 |
储存温度 | 室温 (15°C以下阴凉干燥处) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 湿气 (分解) |
包装和容器 | 250MG-带有塑料内管的玻璃瓶 (查看图片) |
CAS RN | 50978-45-5 |
Reaxys-RN | 21741916 |
PubChem物质ID | 160871419 |
技术规格
Appearance | White to Almost white powder to crystal |
Purity(GC) | min. 98.0 % |
物性(参考值)
溶解性(微溶于) | 二甲基甲酰胺 |
GHS
相关法规
新化学物质备案回执号 | B1A232216048 |
运输信息
监管条件代码(*) |
应用
Easily Accessible and Highly Reactive Crystalline CO Surrogate, N-formylsaccharin
Typical Procedure (entry 1):
Pd(OAc)2 (10.1 mg, 0.045 mmol, 3.0 mol%), DPPB (28.8 mg, 0.068 mmol, 4.5 mol%), N-formylsaccharin (475 mg, 2.25 mmol, 1.5eq.), and Na2CO3 (238 mg, 2.25 mmol, 1.5eq.) are added to a 30 mL test tube, which is then evacuated and backfilled three times with N2. A solution of bromobenzene (158 µL, 1.50 mmol) and Et3SiH (311 µL, 1.95 mmol, 1.3eq.) in DMF (6 mL) is added to the test tube under N2. The tube is immediately sealed and the mixture is stirred efficiently for 10 min at rt. The mixture is subsequently warmed to 75 °C and stirred for a further 16 h. The reaction mixture is cooled to rt, then diluted with Et2O (15 mL), and washed with H2O (15 mL). The aqueous layer is extracted two times with Et2O (15 mL). The combined organic layer is dried over MgSO4, filtered, and concentrated. The obtained residue is purified by flash column chromatography on silica gel (eluent: 3–5% Et2O in n-pentane) to provide benzaldehyde as a colorless oil (132 mg, 83%).
Pd(OAc)2 (10.1 mg, 0.045 mmol, 3.0 mol%), DPPB (28.8 mg, 0.068 mmol, 4.5 mol%), N-formylsaccharin (475 mg, 2.25 mmol, 1.5eq.), and Na2CO3 (238 mg, 2.25 mmol, 1.5eq.) are added to a 30 mL test tube, which is then evacuated and backfilled three times with N2. A solution of bromobenzene (158 µL, 1.50 mmol) and Et3SiH (311 µL, 1.95 mmol, 1.3eq.) in DMF (6 mL) is added to the test tube under N2. The tube is immediately sealed and the mixture is stirred efficiently for 10 min at rt. The mixture is subsequently warmed to 75 °C and stirred for a further 16 h. The reaction mixture is cooled to rt, then diluted with Et2O (15 mL), and washed with H2O (15 mL). The aqueous layer is extracted two times with Et2O (15 mL). The combined organic layer is dried over MgSO4, filtered, and concentrated. The obtained residue is purified by flash column chromatography on silica gel (eluent: 3–5% Et2O in n-pentane) to provide benzaldehyde as a colorless oil (132 mg, 83%).
References
应用
Novel Powerful Formylating Reagent
Reference
- 1)N-Formylsaccharin: A new formylating agent
参考文献
技术文章
[TCIMAIL No.158] Novel Powerful N-Formylating Reagent[产品拾贝] 新型的强效甲酰剂
[研究论文] 易得到且反应活性高的晶状CO替代品——N-甲酰基糖精
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