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Published TCIMAIL newest issue No.201
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CAS RN: 134678-17-4 | Product Number: L0217
Lamivudine
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 3TC
- (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
25,00 €
|
1 | 27 |
|
|
| 1G |
157,00 €
|
1 | ≥60 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | L0217 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__1N__3O__3S = 229.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 134678-17-4 |
| Reaxys Registry Number | 5480511 |
| PubChem Substance ID | 87560180 |
| Merck Index (14) | 5352 |
| MDL Number | MFCD00869739 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 175.0 to 179.0 °C |
| Specific rotation [a]20/D | -137.0 to -147.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 177 °C |
| Specific Rotation | -142° (C=1,MeOH) |
| Solubility in water | Soluble |
| Degree of solubility in water | 70,000 mg/l 20 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P314 : Get medical advice/ attention if you feel unwell. |
Related Laws:
| RTECS# | UW7361333 |
Transport Information:
| HS Number | 2934999090 |
Application
Lamivudine: An L-Nucleoside Reverse Transcriptase Inhibitor
Lamivudine is a nucleoside reverse transcriptase inhibitor that active against HIV1, HIV2, and hepatitis B. Lamivudine is a synthetic L-nucleoside analogue of the naturally occurring D-nucleoside 2’-deoxycytidine. Intracellularly, lamivudine is converted by cellular enzymes to the active metabolite, lamivudine-5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxycytidine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine
- Lamivudine A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection
- New and Emerging Treatment of Chronic Hepatitis B (a review)
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