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Published TCIMAIL newest issue No.199
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CAS RN: 209216-23-9 | Product Number: E0899
Entecavir Monohydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€60.00
|
Contact Us | 10 |
|
| 200MG |
€181.00
|
Contact Us | 20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | E0899 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__5N__5O__3·H__2O = 295.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 209216-23-9 |
| Related CAS RN
|
142217-69-4 |
| Reaxys Registry Number | 14632881 |
| PubChem Substance ID | 253660820 |
| Merck Index (14) | 3595 |
| MDL Number | MFCD09754448 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +34.0 to +38.0 deg(C=0.25, H2O)(calcd.on anh.substance) |
| Water | 4.0 to 9.0 % |
Properties (reference)
| Melting Point | 259 °C(dec.) |
| Specific Rotation | 36° (C=0.25,H2O) |
| Degree of solubility in water | 2.4 g/l |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
Cefdinir: A Third-Generation Cephalosporin More Active Against Gram-Positive Organisms
Entecavir (ETV or BMS-200475), a deoxyguanosine analog, is rapidly phosphorylated in vivo to the active intracellular 5'-triphosphate form that inhibits replication of hepatitis B virus (HBV) and shows reduced activity against other viruses, including HIV-1, influenza and herpes simplex viruses. Entecavir is a nucleoside reverse transcriptase inhibitor (NRTI). It inhibits reverse transcription in the viral replication process. (The product is for research purpose only.)
References
- BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
- Metabolic studies on BMS-200475, a new antiviral compound active against hepatitis B virus
- Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro
- Potent efficacy of entecavir (BMS-200475) in a Duck model of hepatitis B virus replication
- Inhibition of hepatitis B virus polymerase by entecavir
- Entecavir: A review of its use in chronic hepatitis B
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