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CAS RN: 123318-82-1 | Product Number: C2500
Clofarabine
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Purity: >98.0%(HPLC)
Synonyms:
- 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€43.00
|
1 | 6 |
|
| 100MG |
€155.00
|
3 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2500 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__1ClFN__5O__3 = 303.68 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 123318-82-1 |
| Reaxys Registry Number | 4882539 |
| PubChem Substance ID | 135727330 |
| Merck Index (14) | 2372 |
| MDL Number | MFCD00871077 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 227 °C |
| Maximum Absorption Wavelength | 263 nm (EtOH) |
GHS
Related Laws:
| RTECS# | UD7473000 |
Transport Information:
| HS Number | 2934999090 |
Application
Studies on Antitumor Activity
References
- Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate
- W. B. Parker, S. C. Shaddix, C. H. Chang, E. L. White, L. M. Rose, R. W. Brockman, Cancer Res. 1991, 51, 2386.
- DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine
- T. Yamauchi, B. J. Nowak, M. J. Keating, W. Plunkett, Clin. Cancer Res. 2001, 7, 3580.
- Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
- Discovery and development of clofarabine: a nucleoside analogue for treating cancer
- Mechanisms of anti-cancer action and pharmacology of clofarabine
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