Peptide Chemistry

Peptides are chains of amino acid residues connected via amide linkages. Peptides composed up to 10 amino acid residues are referred to small peptides, while those with up to 100 residues are known as (poly)peptides. A peptide moiety forms prime constituent of not only proteins but also aspartame, an artificial non-saccharide sweetener. Peptides serve various functions in organisms, especially the peptide hormones which play important roles in signal transductions. Some synthetic peptides can also be used as reagents for biochemical research and in pharmacy.¹⁾
Since the number of naturally occurring bioactive peptides is limited and the genes corresponding to the peptides are usually unknown, peptide synthesis enables the further research for functional analysis of the peptides. To date, peptides with several dozen of residues can be obtained by solid phase peptide synthesis. Peptides with a small number of residues can also be prepared in a large scale by liquid phase synthesis. This section shows reagents used in peptide synthesis.

References

• 1) V. Marx, Chem. Eng. News 2005, 83, 18.
• 2) Handbook of Biologically Active Peptides, ed. by A. J. Kastin, Academic Press, Boston, 2006.