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CAS RN: 125-84-8 | Product Number: A1947
DL-Aminoglutethimide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-(4-Aminophenyl)-3-ethylpiperidine-2,6-dione
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹2,400.00
|
4 | 28 |
|
| 5G |
₹6,100.00
|
4 | 23 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A1947 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__6N__2O__2 = 232.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 125-84-8 |
| Reaxys Registry Number | 210656 |
| PubChem Substance ID | 87558926 |
| Merck Index (14) | 440 |
| MDL Number | MFCD00010122 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 150.0 to 154.0 °C |
| Solubility in Acetone | very faint turbidity |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 152 °C |
| Solubility (soluble in) | Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | MA4026950 |
Transport Information:
Application
DL-Aminoglutethimide: A Potent but Nonselective Aromatase Inhibitor
DL-Aminoglutethimide is a first generation, and a potent but nonselective aromatase inhibitor. Aminoglutethimide inhibits the enzymatic side-chain cleavage of cholesterol [C0318] to pregnenolone [P0786], mediated through the binding of aminoglutethimide to cytochrome P 450， resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens. Besides, aminoglutethimide-P450 complexes block enzymatic 11- and 18-hydroxylation steps required for the aromatization of androgens to estrogens. Aminoglutethimide is used for the treatment of Cushing’s syndrome, breast and prostate cancer. (The product is for research purpose only.)
References
- Aminoglutethimide (Elipten) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial
- Stereoselective inhibition of aromatase by enantiomers of aminoglutethimide
- Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland
- Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer (a review)
- History of aromatase: saga of an important biological mediator and therapeutic target
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