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CAS RN: 1451042-18-4 | Product Number: A2897
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide
![Chemical Structure of N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide](/medias/A2897.jpg?context=bWFzdGVyfHJvb3R8NDkxMDZ8aW1hZ2UvanBlZ3xhRGN4TDJneU1pODRPVEU1TmpnMU1UTTJOREUwTDBFeU9EazNMbXB3Wnd8NTFhYmEyNTk5NmJhOGIzZTM2ZDM5YjZjYjFhMDc4ZDU0MDk2ZTNmNzBmN2Q3YWRiZjZjMjBlYTYwNDkxNjljYw "N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide")
![Thumbnail of N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide](/medias/A2897.jpg?context=bWFzdGVyfHJvb3R8MTUyNDZ8aW1hZ2UvanBlZ3xhR015TDJoalppODRPVE16TVRJM01qSTFNemMwTDBFeU9EazNMbXB3Wnd8YmY2ZmRiMTg3ZGU4NTM1ZTZjODIxY2U3MmZkOTI0ODczZjE0ZDliZmQzYzI1YWRmNmQyMDkxMzQ0MGY3YzEzYg)
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![N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide")
Purity: >95.0%(HPLC)
Synonyms:
- T 247
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 5MG |
₹6,600.00
|
Contact Us | 9 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A2897 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__1__9N__5OS = 389.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 1451042-18-4 |
| PubChem Substance ID | 354333140 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 17.00 to 19.00 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 236 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
A Histone Deacetylase 3 (HDAC3) Selective Inhibitor
Suzuki et al. have reported that this compound (T247) shows potent histone deacetylase 3 (HDAC3) inhibitions, whereas it does not strongly inhibit other isozymes. T247 also induces a dose-dependent selective NF-kB acetylation in human colon cancer HCT116 cells, indicating selective inhibition of HDAC3 in the cells. In addition, T247 induced growth inhibition of cancer cells, and activated HIV gene expression in latent HIV-infected cells. These findings indicate that T247 alone or a combination agent may be useful in the treatment of cancer or HIV infection. (The product is for research purpose only.)
References
- Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly
- Triazole ring-containing amides, their preparation, and their use for pharmaceuticals and HDAC3 inhibitors
- N. Miyata, T. Suzuki, Y. Kasuya, JP 2013-170164 A
PubMed Literature
Documents
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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