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CAS RN: 104075-48-1 | Product Number: A2956
Atipamezole Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹5,300.00
|
1 | 6 |
|
| 100MG |
₹13,300.00
|
1 | 8 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A2956 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__6N__2·HCl = 248.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 104075-48-1 |
| Related CAS RN
|
104054-27-5 |
| Reaxys Registry Number | 8164642 |
| PubChem Substance ID | 354334070 |
| Merck Index (14) | 861 |
| MDL Number | MFCD06407819 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 218.0 to 222.0 °C |
Properties (reference)
| Melting Point | 220 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Ethanol |
| Solubility (insoluble in) | Acetone |
GHS
Related Laws:
| RTECS# | NI6139000 |
Transport Information:
Application
Atipamezole: An α2-Adrenoceptor Antagonist
Atipamezole hydrochloride is a potent and selective α2-adrenoceptor antagonist with an imidazole structure. In animals, it promotes the release of the neurotransmitter noradrenaline in the central as well as in the peripheral nervous systems. The α2/α1 selectivity ratio are considerably higher than those of yohimbine hydrochloride [Y0002]. Unlike many other α2-adrenoceptor antagonists, atipamezole has negligible affinity for 5-HT1A receptors. Atipamezole hydrochloride is used for the reversal of an α2-agonist (e.g. xylazine hydrochloride [X0059]) induced sedation in animals. (The product is for research purpose only.)
References
- Highly selective and specific antagonism of central and peripheral α2-adrenoceptors by atipamezole
- Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behavior in comparison with yohimbine
- Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors
- Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective α2-adrenoceptor antagonist
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