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CAS RN: 55079-83-9 | Product Number: A3097
Acitretin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic Acid
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
₹4,000.00
|
Contact Us | 16 |
|
| 250MG |
₹9,200.00
|
Contact Us | 37 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3097 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__6O__3 = 326.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 55079-83-9 |
| Reaxys Registry Number | 2158933 |
| PubChem Substance ID | 354335416 |
| Merck Index (14) | 112 |
| MDL Number | MFCD00866632 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 230 °C |
| Maximum Absorption Wavelength | 352 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
Application
Acitretin: A Retinoic Acid Derivative that is an Active Metabolite of Etretinate
Acitretin is a retinoic acid (vitamin A acid) [R0064] derivative that is the major active metabolite of etretinate [E1293]. Acitretin s used for the treatment of severe psoriasis and other dyskeratoses, but the precise mechanism of action of it is not fully understood. However, the pharmacological profile of acitretin suggests that it acts by normalizing pathological changes in epidermal and dermal skin, particularly inhibiting hyperkeratinization and cell differentiation. In addition, acitretin reportedly has teratogenic potential. (The product is for research purpose only.)
References
- Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro
- Acitretin: a review of its pharmacology and therapeutic use
- Systemic retinoids in chemoprevention of non-melanoma skin cancer (a review)
- Acitretin in dermatology: a review
- Comparative teratogenicity of nine retinoids in the rat
PubMed Literature
Product Articles
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Specifications
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