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CAS RN: 485-49-4 | Product Number: B1890

(+)-Bicuculline

Chemical Structure of (+)-Bicuculline
×
× (+)-Bicuculline

Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
SDS | Specifications | C of A & Other Certificates | Analytical Charts

General Information | Specifications & Properties | Safety & Regulations | Applications & Literature

Explanatory notes for this page

25MG
₹3,800.00
 2   ≥40 
100MG
₹12,300.00
 3   9  

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Product Number B1890
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__0H__1__7NO__6 = 367.36 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
Packaging and Container 25MG-Glass Bottle with Plastic Insert (View image)
CAS RN 485-49-4
Reaxys Registry Number 98786
PubChem Substance ID 125308663
SDBS (AIST Spectral DB) 16661
Merck Index (14) 1203
MDL Number

MFCD00005006
Specifications
Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 195.0 to 199.0 °C
Specific rotation [a]20/D +127.0 to +132.0 deg(C=1, CHCl3)
Properties (reference)
Melting Point 197 °C
Specific Rotation 132° (C=1,CHCl3)
Maximum Absorption Wavelength 325 nm
Solubility (soluble in) Benzene
Solubility (slightly sol. in) Chloroform
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
H401 : Toxic to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
Related Laws:
RTECS# LV0909840
Transport Information:
UN Number UN1544
Class 6.1
Packing Group III
Application
Reagents convulsion or paralysis model

References


Application
GABA Receptor Antagonist

B1890

GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nerve system and GABAA, GABAB, and GABAC receptors have been identified as the major receptors.1) GABAA and GABAC receptors are members of transmitter-gated ion channels, and GABAB receptors are the receptors that are coupled to G-protein and activate secondary messenger systems and Ca2+ and K+ ion channels.1)
Bicuculline (1) is a phthalide isoquinoline alkaloid isolated from a variety of plants, Dicentra, Corydalis, and Adlumia, genera of the Fumariaceae family. GABAA receptors are selectively blocked by 1.1-3) Affinity of 1 and the receptors have been studied by using mutational forms of recombinant receptor proteins.3) 1 and its quaternary salts also have actions other than as GABA-receptor antagonists including inhibition of cholinesterase, effects on 5-HT3, nicotinic, and N-methyl-D-aspartate (NMDA) receptors.2,3)

References


PubMed Literature


Documents

Product Articles
[TCIMAIL No.160] GABA Receptor Antagonist
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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