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CAS RN: 183322-45-4 | Product Number: B4945
PD 153035 Hydrochloride
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Purity: >97.0%(HPLC)
Synonyms:
- N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine Hydrochloride
- 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹4,200.00
|
Contact Us | 13 |
|
| 100MG |
₹8,700.00
|
Contact Us | 23 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4945 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4BrN__3O__2·HCl = 396.67 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 183322-45-4 |
| Reaxys Registry Number | 7400679 |
| PubChem Substance ID | 354333249 |
| MDL Number | MFCD01074805 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Argentometric Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 265 °C |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
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Application
PD 153035: An Inhibitor of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase
PD 153035 hydrochloride is a specific and potent inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. EGFR is the cell-surface receptor for members of the epidermal growth factors (EGFs) that play a central role in regulating cell division and death. EGFR tyrosine kinase is activated by binding of EGFs. This binding causes cell differentiation and proliferation. Therefore, PD 153035 hydrochloride is often used for cancer research.
References
- A specific inhibitor of the epidermal growth factor receptor tyrosine kinase
- Tyrosine kinase inhibitors: unusually steep structure-activity relationship for analogs of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor
- PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner
- Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors
- Anilinodialkoxyquinazolines: Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Potential Tumor Imaging Probes
- EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice
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