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CAS RN: 124-87-8 | Product Number: C0375

Picrotoxin (Picrotoxinin + Picrotin)

Purity: >94.0%(HPLC)
  • Cocculin (Picrotoxinin + Picrotin)
4   Contact Us ≥20 
1   Contact Us ≥20 

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Product Number C0375
Purity / Analysis Method >94.0%(HPLC)
Molecular Formula / Molecular Weight C__3__0H__3__4O__1__3 = 602.59  
Physical State (20 deg.C) Solid
CAS RN 124-87-8
PubChem Substance ID 87565507
SDBS (AIST Spectral DB) 10888
Merck Index (14) 7415
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC)(CAD) min. 94.0 %(Picrotoxinin and Picrotin mixture)
Properties (reference)
Melting Point 200 °C
Specific Rotation -34° (C=4,EtOH)
Solubility in water Practically insoluble
Solubility (soluble in) Ethanol
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# TJ9100000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group II
Picrotoxin: A Natural Sesquiterpene Antagonist of GABAA Receptors

Picrotoxin is a sesquiterpene that occurs naturally in the fruit of the Anamirta cocculus which a wild woody climber, distributed throughout India as well as South-East Asia. Picrotoxin is a mixture of two compounds, picrotoxinin and picrotin. Of the two compounds, picrotoxinin is the active ingredient. Picrotoxinin is a naturally occurring poison that a noncompetitive antagonist of GABAA receptors (GABARs), the primary mediators of inhibitory neurotransmission in the nervous system. Picrotoxinin prevents ion flow through the chloride channel activated by GABA in the GABAR, a member of the cys-loop, ligand-gated ion channel superfamily. (The product is for research purpose only.)


PubMed Literature

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