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CAS RN: 124-87-8 | Product Number: C0375
Picrotoxin (Picrotoxinin + Picrotin)
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Purity: >94.0%(HPLC)
Synonyms:
- Cocculin (Picrotoxinin + Picrotin)
Documents:
| Size | Unit Price | Hyderabad | Chennai | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
₹3,900
|
4 | Contact Us | ≥20 |
|
| 5G |
₹11,500
|
1 | Contact Us | ≥20 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day & Chennai stocks will be dispatched in 3-6 working days.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*Change currency to place order in USD.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 94.0 %(Picrotoxinin and Picrotin mixture) |
Properties (reference)
| Melting Point | 200 °C |
| Specific Rotation | -34° (C=4,EtOH) |
| Solubility in water | Practically insoluble |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | TJ9100000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
Application
Picrotoxin: A Natural Sesquiterpene Antagonist of GABAA Receptors
Picrotoxin is a sesquiterpene that occurs naturally in the fruit of the Anamirta cocculus which a wild woody climber, distributed throughout India as well as South-East Asia. Picrotoxin is a mixture of two compounds, picrotoxinin and picrotin. Of the two compounds, picrotoxinin is the active ingredient. Picrotoxinin is a naturally occurring poison that a noncompetitive antagonist of GABAA receptors (GABARs), the primary mediators of inhibitory neurotransmission in the nervous system. Picrotoxinin prevents ion flow through the chloride channel activated by GABA in the GABAR, a member of the cys-loop, ligand-gated ion channel superfamily. (The product is for research purpose only.)
References
- Picrotoxin-like channel blockers of GABA receptors (a review)
PubMed Literature
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