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CAS RN: 69-09-0 | Product Number: C2481
Chlorpromazine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride
Documents:
| Size | Unit Price | Hyderabad | Chennai | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
₹3,200
|
11 | Contact Us | ≥20 |
|
| 25G |
₹8,800
|
4 | Contact Us | 19 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day & Chennai stocks will be dispatched in 3-6 working days.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*Change currency to place order in USD.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C2481 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9ClN__2S·HCl = 355.32 |
| Physical State (20 deg.C) | Solid |
| Condition to Avoid | Light Sensitive |
| CAS RN | 69-09-0 |
| Related CAS RN | 50-53-3 |
| Reaxys Registry Number | 3779989 |
| PubChem Substance ID | 125307954 |
| Merck Index (14) | 2185 |
| MDL Number | MFCD00012654 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 195.0 to 199.0 °C |
Properties (reference)
| Melting Point | 197 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol,Ethanol |
| Solubility (insoluble in) | Benzene,Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H330 : Fatal if inhaled. H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | SO1750000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
Application
Chlorpromazine Hydrochloride: A Dopamine Inhibitor with Antipsychotic Activity
Chlorpromazine hydrochloride is a phenothiazine antipsychotic agent. The precise mechanism of actions is not fully understood. However, chlorpromazine works as a dopamine inhibitor, and the antagonism central dopaminergic function may be related to the therapeutic effect in psychotic conditions. Chlorpromazine can also produce α-adrenergic receptor antagonist action which may produce hypotension. Besides, it is reported that UV irradiation of chlorpromazine produces reactive free radicals which have DNA damaging properties. (The product is for research purpose only.)
References
- Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
- Expression and pharmacological characterization of the human D3 dopamine receptor
- Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors
- Review of the genotoxic properties of chlorpromazine and related phenothiazines
- Fifty years chlorpromazine: a historical perspective (a review)
- Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography
- Extraction and determination of trace amounts of chlorpromazine in biological fluids using hollow fiber liquid phase microextraction followed by high-performance liquid chromatography
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