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CAS RN: 167221-71-8 | Product Number: C3503
Clevidipine
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Purity: >98.0%(HPLC)
Synonyms:
- 3-[(Butyryloxy)methyl] 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Aicd 3-[(Butyryloxy)methyl] 5-Methyl Ester
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
₹4,800.00
|
Contact Us | 2 |
|
| 1G |
₹6,400.00
|
Contact Us | 9 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3503 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__3Cl__2NO__6 = 456.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 167221-71-8 |
| Reaxys Registry Number | 8450029 |
| PubChem Substance ID | 354335546 |
| Merck Index (14) | 2352 |
| MDL Number | MFCD00940070 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
| Melting point | 141.0 to 145.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 143 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.1 g/l |
GHS
Related Laws:
Transport Information:
Application
Clevidipine: An Ultrashort-Acting 1,4-Dihydropyridine L-Type Calcium Channel Antagonist
Clevidipine is an ultrashort-acting L-type calcium channel antagonist with selectivity for arteriolar vasodilatation. L-type calcium channels mediate the influx of calcium during depolarization in arterial smooth muscle. Clevidipine particularly induce a relaxation of the muscle in arterial bed, and reduces arterial blood pressure by decreasing systemic vascular resistance directly. On the other hand, clevidipine does not reduce cardiac filling pressure, confirming lack of effects on the venous vessels. Clevidipine is a 1,4-dihydropyridine calcium channel antagonist, structurally related to felodipine [F0814]. (The product is for research purpose only.)
References
- In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolized by esterases, in different animal species and man
- Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs
- Clevidipine. A review of its use in the management of acute hypertension
- Determination of an ultrashort-acting antihypertensive dihydropyridine, clevidipine, in blood using capillary gas chromatography-mass spectrometry and of the primary metabolite using liquid chromatography and fluorescence detection
- Enantioselective pharmacokinetics of the enantiomers of clevidipine following intravenous infusion of the racemate in essential hypertensive patients
PubMed Literature
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