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CAS RN: 167221-71-8 | Product Number: C3503

Clevidipine


Purity: >98.0%(HPLC)
Synonyms:
  • 3-[(Butyryloxy)methyl] 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Aicd 3-[(Butyryloxy)methyl] 5-Methyl Ester
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Product Number C3503
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__3Cl__2NO__6 = 456.32  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 167221-71-8
Reaxys Registry Number 8450029
PubChem Substance ID 354335546
Merck Index (14) 2352
MDL Number

MFCD00940070

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 96.0 %
Melting point 141.0 to 145.0 °C
Properties (reference)
Melting Point 143 °C
Solubility in water Insoluble
Degree of solubility in water 0.1 g/l  
GHS
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Application
Clevidipine: An Ultrashort-Acting 1,4-Dihydropyridine L-Type Calcium Channel Antagonist

Clevidipine is an ultrashort-acting L-type calcium channel antagonist with selectivity for arteriolar vasodilatation. L-type calcium channels mediate the influx of calcium during depolarization in arterial smooth muscle. Clevidipine particularly induce a relaxation of the muscle in arterial bed, and reduces arterial blood pressure by decreasing systemic vascular resistance directly. On the other hand, clevidipine does not reduce cardiac filling pressure, confirming lack of effects on the venous vessels. Clevidipine is a 1,4-dihydropyridine calcium channel antagonist, structurally related to felodipine [F0814]. (The product is for research purpose only.)

References


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