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Published TCIMAIL newest issue No.199 | Product Document Searching Made Easy by 2D Code! | [TCIPracticalExample] Ullmann-Type Coupling Reaction Using...
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CAS RN: 114289-47-3 | Product Number: C4099
CI 976
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Purity: >95.0%(HPLC)
Synonyms:
- PD 128042
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
₹9,500.00
|
Contact Us | 20 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C4099 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__9NO__4 = 393.57 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 114289-47-3 |
| Reaxys Registry Number | 5831010 |
| MDL Number | MFCD00869662 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 58.0 to 62.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 60 °C |
GHS
Related Laws:
| RTECS# | JR2052000 |
Transport Information:
Application
Cl-976: An Orally Active and Selective Inhibitor of Acyl-Coenzyme A (ACAT)
CI-976 is an orally active and selective inhibitor of Acyl-Coenzyme A (ACAT, also known as sterol O-acyltransferase or SOAT), which is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-CoA.1) Recently, many studies have suggested that ACAT-1 (SOAT-1) plays a critical role in cancer initiation and progression and is an attractive target for novel anticancer therapies.2,3) For this reason, the inhibitor CI-976 is being used in cancer research. (The product is for research use only.)
References
- 1) In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT
- 2) Cholesterol metabolism: New functions and therapeutic approaches in cancer (a review)
- 3) Targeting Sterol O-Acyltransferase/Acyl-CoA: Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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