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CAS RN: 23674-86-4 | Product Number: D5579
Difluprednate
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Purity: >98.0%(HPLC)
Synonyms:
- 6α,9α-Difluoroprednisolone-21-acetate-17-butyrate
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
₹6,600.00
|
Contact Us | 7 |
|
| 250MG |
₹16,500.00
|
Contact Us | 1 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D5579 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__3__4F__2O__7 = 508.56 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 23674-86-4 |
| Reaxys Registry Number | 2068619 |
| PubChem Substance ID | 468591425 |
| Merck Index (14) | 3152 |
| MDL Number | MFCD00214273 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 191.0 to 195.0 °C |
Properties (reference)
| Melting Point | 193 °C |
| Specific Rotation | 31° (C=2,Dioxane) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.008 g/l |
| Solubility (soluble in) | Methanol, Ethanol, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | TU3831500 |
Transport Information:
Application
Difluprednate: A Potent Topical Corticosteroid
Difluprednate (DFBA) is a potent topical corticosteroid owing to its high affinity for glucocorticoid receptors. Actually, it is a prodrug that is converted to its active metabolite difluoroprednisolone butyrate (DFB) by deacetylation after penetration. Corticosteroids are commonly used to control inflammation, and difluprednate ophthalmic emulsion is commonly used for the treatment of anterior uveitis. There is no generally accepted explanation for the mechanism of action of corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory anti-inflammatory proteins, collectively called lipocortins, and inhibiting the release of arachidonic acid from membrane phospholipids by phospholipase A2. (The product is for research purpose only.)
References
- Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate
- Ocular Distribution of Difluprednate Ophthalmic Emulsion 0.05% in Rabbits
- Difluprednate for inflammatory eye disordes (a review)
- Analysis of an anti-inflammatory steroidal drug, difluprednate, in aqueous humor by combination of semi-micro HPLC and column switching method
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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