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CAS RN: 302962-49-8 | Product Number: D5949

Dasatinib


Purity: >95.0%(T)(HPLC)
Synonyms:
  • N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]thiazole-5-carboxamide
Documents:
1G
₹10,000.00
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5G
₹24,100.00
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Product Number D5949
Purity / Analysis Method >95.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__6ClN__7O__2S = 488.01 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (<0°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 302962-49-8
Reaxys Registry Number 9966762
PubChem Substance ID 468591660
MDL Number

MFCD11046566

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
NMR confirm to structure
Properties (reference)
Melting Point 280 °C
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# XJ3466000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
Application
Dasatinib: A Multitargeted Inhibitor of Tyrosine Kinases

Dasatinib (BMS-354825) is an oral, multitargeted inhibitor of tyrosine kinases, including BCR-ABL fusion protein, SRC family kinases (SRC, LCK, YES, FYN), c-KIT, erythropoietin-producing hepatocellular receptor A2 (EPHA2), and platelet-derived growth factor receptor β (PDGFRβ). In vitro studies have shown that dasatinib is active in leukemic cell lines representing variants of imatinib mesylate [I0936] sensitive and resistant disease. Dasatinib inhibits the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. (The product is for research purpose only.)

References

Documents (Note: Some products will not have analytical charts available.)
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