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CAS RN: 189279-58-1 | Product Number: D6143
Delafloxacin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic Acid
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
₹7,800.00
|
3 | ≥40 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D6143 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__2ClF__3N__4O__4 = 440.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 189279-58-1 |
| Reaxys Registry Number | 9168989 |
| MDL Number | MFCD09955301 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 241.0 to 245.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 243 °C |
GHS
Related Laws:
Transport Information:
Application
Delafloxacin: An Anionic Fluoroquinolone Antibiotic against Levofloxacin-Resistant Strains and MRSA
Delafloxacin (ABT-492) is an anionic fluoroquinolone antibiotic lacking a basic substituent at position 7. Delafloxacin has broad-spectrum bactericidal activity in vitro against Gram-positive and Gram-negative bacteria, including levofloxacin-resistant strains of Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). The antibacterial activity of delafloxacin is due to inhibition of both bacterial topoisomerase IV and DNA gyrase (topoisomerase II) enzymes, which are required for bacterial DNA replication, transcription, repair, and recombination. (The product is for research purpose only.)
References
- In Vitro Activities of ABT-492, a New Fluoroquinolone, against 155 Aerobic and 171 Anaerobic Pathogens Isolated from Antral Sinus Puncture Specimens from Patients with Sinusitis
- In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone
- Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus
- Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy (a review)
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