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Product Document Searching Made Easy by 2D Code! | [Product Highlights] Endogenous Biotin-Blocking Reagent...Maximum quantity allowed is 999
CAS RN: 1678540-23-2 | Product Number: E1267
Ethyl (11bR)-4-Amino-2,6-bis(3,5-di-tert-butylphenyl)-4,5-dihydro-3H-cyclohepta[1,2-a:7,6-a']dinaphthalene-4-carboxylate
![Ethyl (11bR)-4-Amino-2,6-bis(3,5-di-tert-butylphenyl)-4,5-dihydro-3H-cyclohepta[1,2-a:7,6-a']dinaphthalene-4-carboxylate No-Image](/medias/E1267.jpg?context=bWFzdGVyfHJvb3R8NzE4MDJ8aW1hZ2UvanBlZ3xhREV6TDJnMVlTODRPVEl4TmpZek5qWTRNalUwTDBVeE1qWTNMbXB3Wnd8YTE2MGM4Y2FhYzFlMDNlYjEwYTk5NTg1NDYwOTc5ZmE1M2EwNDhiYTFiZjM5ZDlkY2VjYjE4ODM3MmM1OWJjYQ)
Purity: >97.0%(HPLC)
- (11bR)-4-Amino-2,6-bis(3,5-di-tert-butylphenyl)-4,5-dihydro-3H-cyclohepta[1,2-a:7,6-a']dinaphthalene-4-carboxylic Acid Ethyl Ester
Size | Unit Price | Hyderabad | Japan* | Quantity |
---|---|---|---|---|
50MG |
₹15,400.00
|
Contact Us | 2 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Product Number | E1267 |
Purity / Analysis Method | >97.0%(HPLC) |
Molecular Formula / Molecular Weight | C__5__4H__6__3NO__2 = 758.10 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Condition to Avoid | Heat Sensitive |
CAS RN | 1678540-23-2 |
PubChem Substance ID | 354334205 |
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 97.0 area% |
NMR | confirm to structure |
Pictogram |
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Signal Word | Warning |
Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
To a stirred solution of 1 (10 mol%), N-chlorosuccinimide (1.5 eq.) in toluene is added α-alkyl-β-ketocarboxylic acid (1 eq.) and the reaction mixture is stirred under darkness. After completion, the resulting mixture is subjected directly silica gel column chromatography (hexane:dichloromethane) to give the corresponding α-chloroketone.
References
- Enantioselective decarboxylative chlorination of β-ketocarboxylic acids
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To a solution of the chiral amine catalyst [E1267] (20 mg, 0.026 mmol, 10 mol%) in toluene (0.54 mL) is added 3,5-dinitrobenzoic acid (5.5 mg, 0.026 mmol, 10 mol%), 2-phenylpropionaldehyde (52 mg, 0.39 mmol, 1.5 eq.), and N-fluorobenzenesulfonimide (NFSI) (0.26 mmol, 82 mg, 1 eq.) at 0 °C. The reaction mixture is stirred at 0 °C for 48 h, then poured into CH3OH/CH2Cl2 (1:4, 1.3 mL) at 0 °C. To this solution, NaBH4 (1.6 mmol, 6 eq.) is added, and the mixture is stirred at room temperature for 1 h. The reaction is quenched with saturated aq.NH4Cl, and the mixture is extracted with Et2O. The organic layer is dried over Na2SO4, and concentrated. The residue is purified by silica gel chromatography (eluent: hexane/ethyl acetate = 3/1) to give (S)-2-fluoro-2-phenylpropan-1-ol (34.5 mg, 86% yield based on NFSI, 95% ee) as a white solid.
References
Documents
[Research Articles] An Enantioselective Fluorination of α-Branched Aldehydes Using Newly Developed Chiral Amine Catalyst
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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