Fludarabine (F-ara-A), an antimetabolite antineoplastic nucleoside, is a 2-fluorinated nucleoside analog of the antiviral agent vidarabine (ara-A) [
V0098] that is relatively resistant to deamination by adenosine deaminase. F-ara-A is rapidly phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP (F-ara-ATP). The active metabolite acts by inhibiting DNA and RNA polymerases thus preventing DNA and RNA syntheses in proliferating cells. In clinical, its monophosphate, F-ara-AMP, is used for the treatment of chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin's lymphoma. (The product is for research purpose only.)