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CAS RN: 3258-02-4 | Product Number: H1803
N4-Hydroxycytidine
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Purity: >95.0%(HPLC)
Synonyms:
- EIDD-1931
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyamino)pyrimidin-2(1H)-one
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹7,400.00
|
Contact Us | 10 |
|
| 100MG |
₹15,600.00
|
Contact Us | 20 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | H1803 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__3N__3O__6 = 259.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 3258-02-4 |
| Reaxys Registry Number | 32372 |
| MDL Number | MFCD01675695 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Water | max. 7.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
| RTECS# | YU8080000 |
Transport Information:
Application
Inhibitor Causing Mutations during Viral Replication by RNA-Dependent RNA Polymerase
References
- β-D-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome
- Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
Application
N4-Hydroxycytidine: A Potent and Selective Viral RNA-Dependent RNA polymerase (RdRp) Inhibitor
N4-Hydroxycytidine (EIDD-1931), an antiviral ribonucleoside analog, is an active metabolite of molnupiravir which has activity against a number of RNA viruses.1,2) The RNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for RNA virus replication processes and catalyzes the replication of RNA from an RNA template.3) Because of this, they are often recognized as good targets for antiviral agents. It has been reported that N4-hydroxycytidine acts as a viral RdRp inhibitor of RNA viruses.1,4,5) (The product is for research purpose only.)
References
- 1) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- 2) Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral antiviral agent with activity against SARS-CoV-2
- 3) RNA dependent RNA polymerases: insights from structure, function and evolution
- 4) β-D-N4-Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome
- 5) Small-molecule antiviral β-D-N4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance
Product Articles
[Featured Products] RNA-dependent RNA Polymerase Inhibitors[Product Highlights] Antiviral Reagent Causing Mutations during Viral Replication by RNA-Dependent RNA Polymerase
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